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KMID : 0358420140570040325
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Korean Journal of Obstetrics and Gynecology
2014 Volume.57 No. 4 p.325 ~ p.329
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Congenital leukemia of fetus with acquired AML1 gene duplication
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Kang Sun-Young
Lee Young-Joo
Kim Seung-Chul
Joo Jong-Kil
Park Kyung-Hee
Jun So-Eun
Kim In-Suk
Lee Eun-Yup
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Abstract
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Congenital leukemia is very rare, and its prevalence according to recently published papers is from 1 to 5 per million live births. This can be often diagnosed in postpartum throughout bone marrow biopsy, showing abnormal proliferation of immature blasts and granulocytic precursors. Hepatosplenomegaly is the most common feature which is found during perinatal examinations, that diagnosing is difficult during perinatal period. Hepatosplenomegaly can occur not only in congenital leukemia but in many other cases such as infection which is the most common cause. In other words, congenital leukemia is the one of the rare causes of hepatosplenomegaly. However, this case shows the fetus with the features of hepatosplenomegaly during perinatal period and being diagnosed as congenital leukemia associated with acquired AML1 gene duplication in postpartum through bone marrow biopsy. Due to its rare instance, we are to describe the case with a review of literatures.
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KEYWORD
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AML1 gene, Duplication, Congenital leukemia, Fetal, Hepatosplenomegaly
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